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Tag Archives: genomics
Major new microbial groups expand diversity and alter our understanding of the tree of life
I still believe in revolutions. And sometimes they just happen, almost unnoticed. One such revolution happened on a boring 11th of April 2016 when Laura Hug et al. published their new tree of life in the journal of Nature Microbiology. … Continue reading
Visualize your genome assemblies
Bandage (a Bioinformatics Application for Navigating De novo Assembly Graphs Easily), is a program that creates visualisations of sequence assemblies that you can interact with. When assembling a genome with your favorite assembler, you are usually building graphs, from which … Continue reading
We have the technology. Is sequencing getting better, smaller, faster?
Okay, I know some version of the phrase “recent developments in rapid and affordable sequencing have made blah blah blah possible…” is something you’ve probably read 10,000 times. However, third-generation sequencing platforms have turned out to be pretty darn astounding. … Continue reading
Posted in bioinformatics, evolution, fieldwork, genomics, methods, next generation sequencing
Tagged genomics, MinION, NGS, third-generation sequencing
1 Comment
Small Molecules, Big Differences
Mary Latimer wrote this post as a final project for Stacy Krueger-Hadfield’s Science Communication course at the University of Alabama at Birmingham. She is a third year PhD student at UAB studying miRNAs and methionine restriction. Her hobbies include cats, netflix, … Continue reading
Posted in bioinformatics, blogging, evolution, genomics, natural history, next generation sequencing, RNAseq
Tagged genomics, micro-RNAs, scicomm, Science Communication, Stress
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Hybridization and adaptive radiations
As an iconic system in evolutionary biology, I’ve always been interested in African cichlids and the origins of their diversity1. These cichlids represent an adaptive radiation; they’ve evolved rapidly from a single origin to exploit and speciate into open niches … Continue reading
Diving into the inbreeding depression
This post is going to be a little melodramatic, but I hope that despite all the reading on inbreeding depression, you won’t get depressed. As the media finally started feeding us all the catastrophic news about the impact of global … Continue reading
Posted in conservation, genomics, population genetics, theory
Tagged genomics, inbreeding, inbreeding depression, Isle Royale wolves, pedigree
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There are more microbes than meet the eye: exploring the genomic diversity in an aquifer
First: it’s Tuesday, November 8th, 2016 – before you even think about putting your feet up and reading this post, I hope you’ve managed to wrangle yourself one of those highly prized “I voted” stickers. Now, on to more microbial … Continue reading
Posted in bioinformatics, community ecology, metagenomics, microbiology, next generation sequencing
Tagged ecology, genomics, metagenomics
1 Comment
Making ecology “count”: a review of the why and how of molecular ecology
It’s likely that everyone has been asked by either a friend or family member “What do you do?” Which, depending on what level of detail you shoot for, might be relatively straight forward. The follow-up question, however, can be a … Continue reading
Posted in bioinformatics, community, community ecology, metagenomics
Tagged genomics, methods, omics, review
1 Comment
Divergence and Linked Background Selection
We have widely discussed the reduction in neutral diversity due to demography and linked selection effects (e.g. selective sweeps and hitchhiking, or background selection) in several previous posts (e.g see here, here, and here). However, how linked selection affects neutral divergence … Continue reading
Posted in evolution, genomics, methods, selection, speciation, theory
Tagged ecological speciation, Evolution, genomics, Homo sapiens, natural selection, population genetics
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The trouble with PCR duplicates
The sequencing center just sent your lane of Illumina data. You’re excited. Life is great. You begin to process the data. You align the data. You check for PCR duplicates. 50 percent. Half of your data is garbage. Everything is … Continue reading
Posted in bioinformatics, genomics, methods, next generation sequencing
Tagged genomics, methods, PCR duplicates, RADseq
6 Comments