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Monthly Archives: January 2015
Sex chromosome evolution … in haploids, that is
In diploid organisms, the rates of mutation and recombination played a pivotal role in the evolution of sex-determining regions and, thus, sex chromosomes. We know quite a bit theoretically and empirically in XY systems in mammals and ZW systems in … Continue reading
Posted in evolution, mutation
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SpaceMix, and a brief history of Spatial Genetics
Incorporating spatial data to inform studies of the population demography of a species has a long history of interest. From inferring geographical clines in Principal Components Analyses (Menozzi et al. 1978), using location data as “informative priors” during model-based estimation … Continue reading
Posted in bioinformatics, howto, population genetics, R, software
Tagged data visualization, isolation by distance, methods, population structure
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A population genetic R-evolution
Uphill, both ways, in the snow, without shoes … quite apt when thinking of the dark days, in the not too distant past, in which a separate input file was needed for each popgen analysis in order to use a … Continue reading
Posted in howto, methods, population genetics, R, software, Uncategorized
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Whip it. Population structure and cross-species transmission of Whipworms
This may be my second worm-related post, but it comes from the PLoS journal that is first in my heart: PLoS Neglected Tropical Diseases. And, as the journal name suggests, it is about a neglected tropical disease: the Whipworm (Trichuris … Continue reading
Posted in Uncategorized
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Linking gene expression and phenotype in an emerging model organism
Last week in his post “Transcriptomics in the wild (populations),” TME contributor Noah Snyder-Mackler focused on a recent paper by Alvarez et al. that reviews the last decade of transcriptomic research including the goal of linking gene expression and phenotype. Researchers today routinely collect transcriptomic data for non-model … Continue reading
Posted in genomics, howto, methods, Uncategorized
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Recent Ancestry of the USA and the 100k Genome Project
Holiday presents for pop-gen enthusiasts come in the form of data – boatloads of it! The past two weeks saw the announcements of two neat studies that spell monumental steps toward our understanding of the genetics of mixed populations. With … Continue reading
Posted in genomics, population genetics
Tagged genomics, Homo sapiens, population structure
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