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Author Archives: hollybik
Phylogeny-aware comparisons of microbial communities – EdgePCA and Squash Clustering
I’m jumping on the bandwagon with a blog post about this new PLoS ONE paper (taking the lead from the man in charge in my lab) because the algorithms are just so exciting: Matsen FA IV, Evans SN. (2013) Edge Principal … Continue reading →
Posted in bioinformatics, genomics, next generation sequencing, software
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Tagged 454, edgePCA, Illumina, microbial community, pplacer, squash clustering, UniFrac, UPGMA
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1 Comment
Dramatically reducing sequencing error via Duplex Tag sequencing
An exciting new study was published in PNAS last month, an open access paper entitled “Detection of ultra-rare mutations by next-generation sequencing”. This new method has the potential to open up a new frontier in Next-gen sequencing bioinformatics, since it allows … Continue reading →
Posted in methods, next generation sequencing
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Tagged barcode tags, Illumina, methods, NGS, PCR
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5 Comments