Conservation through hybridization

Mus spretus Photo credit

The Algerian mouse Mus spretus “lent” its pesticide resistance alleles to the European House mouse. How kind! Photo credit University of Valencia 

Human actions have contributed to an unprecedented increase in atmospheric CO2 in the last 250 years, and global temperatures will increase by as many as 4°C by the end of the century. Species can respond to changing conditions in three ways:                     i) individuals and populations can shift their ranges and migrate to more hospitable habitats, ii) individuals can acclimatize to current conditions through physiological plasticity, or iii) populations can adapt through evolution. If none of these options are possible, the species is faced with local or global extinction.
The capacity of a species or population to adapt to climate change depends in part on standing genetic variation, population size, and mutation rate. In an essay recently published in Conservation Biology, Jill Hamilton and Joshua Miller (2015) discuss the potential for gene flow between different species to act as a kind of rescue for species that have low adaptive capacity, injecting beneficial alleles into vulnerable populations, thus facilitating their persistence in the face of climate change.

Where genetic variation is limited, hybridization and introgression may recombine variation to allow rapid evolution in response to changing selective pressures.

Although hybrids have traditionally been undervalued in conservation and are often viewed as a threat to pure species, the conservation value of hybrids and hybridization is gaining recognition (for a recent review, see Jackiw et al. (2015)). The outcomes of hybridization will be context dependent and species-specific and may disrupt existing locally adapted genotypes or introduce unfavorable allele combinations. However, the positive outcomes of hybridization might outweigh the negatives, especially given the rapid pace of climate change. Indeed, Hamilton and Miller (2015) reviewed several case studies that suggest hybridization might be an underutilized management strategy for increasing adaptive capacity. Below is a random sample of the studies they reviewed:
Stelkens et al. (2014) found survival after transfer to increasingly salty environments was higher in interspecific hybrid strains of yeast than in the pure parental strains or intraspecific crosses. Additionally, F2 hybrids outperformed F1 hybrids under increasingly harsh conditions.
Song et al. (2011) and Norris et al. (2015) showed adaptive introgression of alleles that confer resistance to pesticides. Warfarin resistance in the western European house mouse (Mus musculus domesticus) is the result of a single introgressed gene from the Algerian mouse (M. spretus) (Song et al. 2011). A suite of pesticide-resistant alleles confers increased survival in hybrid Anopheles mosquitos (Norris et al. 2015).
Welch and Rieseberg (2002) found that sunflower hybrids exhibit extreme values for traits associated with salt tolerance compared to their parent species (Helianthus annuus x H. petiolaris). Hamilton et al. (2013) showed hybrid genotypes of spruce trees had greater cold tolerance within a certain temperature range compared to the parent species (Picea sitchensis x P. glauca).
Work by Gompert et al. (2006) and Nice et al. (2013) showed hybrid butterflies exhibit morphologies and habitat preferences different from their parent species (Lycaeides anna and L. melissa) which allows them to take novel evolutionary trajectories.
These case studies demonstrate that hybrids can contain genetic variation that is of conservation value and that hybridization can increase the capacity for adaptation under climate change. As suggested by Hamilton and Miller (2015), evolutionary potential is an important component for future conservation and management strategies.
Hamilton, J. A., & Miller, J. M. (2015) Adaptive introgression as a resource for management and genetic conservation in a changing climate. Conservation Biology. DOI: 10.1111/cobi.12574
Jackiw, R. N., Mandil, G., & Hager, H. A. (2015) A framework to guide the conservation of species hybrids based on ethical and ecological considerations. Conservation Biology29, 1041-1051. DOI: 10.1111/cobi.12526
Stelkens, R. B., Brockhurst, M. A., Hurst, G. D., & Greig, D. (2014) Hybridization facilitates evolutionary rescue. Evolutionary Applications, 7, 1209-1217. DOI: 10.1111/eva.12214
Song, Y., Endepols, S., Klemann, N., Richter, D., Matuschka, F. R., Shih, C. H., … & Kohn, M. H. (2011) Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice. Current Biology, 21, 1296-1301. DOI: 10.1016/j.cub.2011.06.043
Norris, L. C., Main, B. J., Lee, Y., Collier, T. C., Fofana, A., Cornel, A. J., & Lanzaro, G. C. (2015) Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets. Proceedings of the National Academy of Sciences, 112, 815-820. DOI: 10.1073/pnas.1418892112
Welch, M. E., & Rieseberg, L. H. (2002) Habitat divergence between a homoploid hybrid sunflower species, Helianthus paradoxus (Asteraceae), and its progenitors. American Journal of Botany, 89, 472-478. DOI: 10.3732/ajb.89.3.472
Hamilton, J. A., Lexer, C., & Aitken, S. N. (2013) Genomic and phenotypic architecture of a spruce hybrid zone (Picea sitchensis × P. glauca). Molecular Ecology22, 827-841. DOI: 10.1111/mec.12007
Gompert, Z., Fordyce, J. A., Forister, M. L., Shapiro, A. M., & Nice, C. C. (2006) Homoploid hybrid speciation in an extreme habitat. Science, 314, 1923-1925. DOI: 10.1126/science.1135875
Nice, C. C., Gompert, Z., Fordyce, J. A., Forister, M. L., Lucas, L. K., & Buerkle, C. A. (2013) Hybrid speciation and independent evolution in lineages of alpine butterflies. Evolution, 67, 1055-1068. DOI: 10.1111/evo.12019

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