What we’re reading: Hyperlocal gene flow, SCOTUS decision on gene patents, and the mother of all microsatellite datasets

Reading at Mont des Arts

In the journals

Pemberton, T.J., Degiorgio, M. & Rosenberg, N. a. 2013. Population structure in a comprehensive genomic data set on human microsatellite variation. G3: Genes, Genomes, Genetics 3: 891–907. doi: 10.1534/g3.113.005728.

Here, we combine eight human population-genetic data sets at the 645 microsatellite loci they share in common, accounting for procedural differences in the production of the different data sets, to assemble a single data set containing 5,795 individuals from 267 worldwide populations.

(Hat tip to Razib Khan, who calls this “the mother of all microsatellite papers.”)

Henss, J.M., Moeller, J.R., Theim, T.J. & Givnish, T.J. 2013. Spatial scales of genetic structure and gene flow in Calochortus albus (Liliaceae). Ecology and Evolution 3: 1461–1470. doi: 10.1002/ece3.566.

Our data on SGS imply that the root-mean-square distance of gene dispersal σ is between 5 and 43 m, and that neighborhood size is between 52 and 194 individuals. Limited gene flow provides a potential explanation for local differentiation seen within species of Calochortus (e.g., in C. albus from the northern Sierras vs. south Coast Ranges [Ownbey 1940]), the high level of local endemism seen across species, the geographic coherence of individual clades of Calochortus, and the parallel adaptive radiations the genus has undergone for several traits in different areas.

Stachowicz, J.J., Kamel, S.J., Hughes, a R. & Grosberg, R.K. 2013. Genetic relatedness influences plant biomass accumulation in eelgrass (Zostera marina). The American Naturalist 181: 715–24. doi: 10.1086/669969.

… contrary to the pattern observed in multispecies assemblages, maximum biomass occurred in assemblages of more closely related individuals.

In the news

The U.S. Supreme Court rules (as most folks seem to be interpreting it) that naturally occurring DNA sequences may not be patented. But the text of the decision [PDF] is drawing complaints from people who know actual biology, and one justice admitted in his concurrence that he doesn’t understand the science.

On the danger of false positives in high-throughput sequencing results.

Thinking about tenure as a safety net.

A good idea for a new blog: Nice R Code. (Get it?)

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About Jeremy Yoder

Jeremy Yoder is a postdoctoral associate in the Department of Plant Biology at the University of Minnesota. He also blogs at Denim and Tweed and Nothing in Biology Makes Sense!, and tweets under the handle @jbyoder.
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  • Massgenomics

    Jeremy, thanks for the link and for reading MassGenomics!