What we’re reading: Selective sweeps in HIV, and rates of molecular evolution in big plants

reading aloud: j reads Harry Potter (3)

In the journals

Leviyang S., 2013  Computational inference methods for selective sweeps arising in acute HIV infection. Genetics 194: 737–752. doi: 10.1534/genetics.113.150862.

HIV escape from CTL [cytotoxic T-lymphocyte] response forms a complex, selective sweep that is difficult to analyze. In this work, we develop a model of initial infection, based on the well-known standard model, that allows for a description of multi-epitope response and the complex mutation pathways of HIV escape.

Lanfear R., Ho S. Y. W., Jonathan Davies T., Moles A. T., Aarssen L., Swenson N. G., Warman L., Zanne A. E., Allen A. P., 2013  Taller plants have lower rates of molecular evolution. Nature Communications 4: 1879. doi: 10.1038/ncomms2836.

Crucially, the long-term rate of mitosis in the apical meristem is likely to be lower in taller plants, because growth slows as plants increase in size and because there are physical limits to the delivery of water and nutrients to apical meristems as they increase in distance from the root system.

In the blogosphere

The story of this retracted Nature paper involves a break-in, tampering with experimental materials, and a hidden camera. Forget the lost publication—who’s got the movie rights?


About Jeremy Yoder

Jeremy Yoder is an Assistant Professor of Biology at California State University, Northridge. He also blogs at Denim and Tweed, and tweets under the handle @jbyoder.
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