What we’re reading

Bookshelf

As we head into the weekend, here’s a few things we’ve noticed that might be worth your screen-time.

In the journals

Smith, S.A., Beaulieu, J.M., Stamatakis, A. & Donoghue, M.J. 2011. Understanding angiosperm diversification using small and large phylogenetic trees. American Journal of Botany 98: 404–14. doi: 10.3732/ajb.1000481.

… we found that diversification rate shifts are not directly associated with the major named clades examined here, with the sole exception of Fabaceae in the GenBank mega-phylogeny. These agreements are encouraging and may support a generality about angiosperm evolution: major shifts in diversification may not be directly associated with major named clades, but rather with clades that are nested not far within these groups.

Makowsky, R., Pajewski, N.M., Klimentidis, Y.C., Vazquez, A.I., Duarte, C.W., Allison, D.B., et al. 2011. Beyond missing heritability: prediction of complex traits. PLoS Genetics 7: e1002051. doi: 10.1371/journal.pgen.1002051.

Using data from the Framingham Heart Study, we explore the genomic prediction of human height in training and validation samples while varying the statistical approach used, the number of SNPs included in the model, the validation scheme, and the number of subjects used to train the model. In our training datasets, we are able to explain a large proportion of the variation in height (h2 up to 0.83, R2 up to 0.96). However, the proportion of variance accounted for in validation samples is much smaller (ranging from 0.15 to 0.36 depending on the degree of familial information used in the training dataset)

In the blogosphere

Requiescat: Godfrey Hewitt.

PLOS Genetics cuts some ethical corners to publish a paper using crowdsourced human genome data.

Where should you submit your next paper?

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About Jeremy Yoder

Jeremy Yoder is an Assistant Professor of Biology at California State University, Northridge. He also blogs at Denim and Tweed, and tweets under the handle @jbyoder.
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