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Tag Archives: population genetics
On (mis)interpreting STRUCTURE/ADMIXTURE results
STRUCTURE, ADMIXTURE and other similar software are among the most cited programs in modern population genomics. They are algorithms that estimate allele frequencies and admixture proportions under the premise that sampled genotypes are derived from one of “K” ancestral populations, … Continue reading
The Great Migration and African-American Genomic History
Over 45 million African-Americans share a recent common history largely shaped by “The Great Migration” (1910-1970) from out of the Southern United States. And yet, the admixture history of the African-American community, and its consequences for public health are little … Continue reading
Posted in genomics, population genetics, United States
Tagged Evolution, gene flow, Illumina, NGS, population genetics, population structure
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Ice-Age Euro-trips
Recent works that attempt to get at human migrations inside Europe paint a complex portrait of migratory events, admixture with archaic hominids, and adaptive evolution to new geographies, and a changing global climate. Analyzing whole genomes of 51 ancient humans … Continue reading
Signatures of the reproductive lottery
In marine populations, effective population sizes are usually several orders of magnitude lower than the census size. This difference is thought to be driven by high fecundity, variation in reproductive success and pronounced early mortality, resulting in genetic drift across generations. In … Continue reading
What does the island fox say?
Small populations are characterized by large drift and reduced efficacy of selection effects, which result in fixation of both advantageous and deleterious alleles, accumulation of homozygosity, and often reduction in population fitness. What with plummeting mammal populations across biota, understanding … Continue reading
Posted in adaptation, evolution, genomics, mutation, natural history, population genetics, selection
Tagged Evolution, genomics, natural selection, population genetics
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Sweeps and Demographic Inference
Population genetics presents us with numerous conundrums – several of which have to do with how the same genomic disposition can be “reached” over evolutionary time with multiple alternate demographic or selective processes. I have discussed several of these issues … Continue reading
Posted in bioinformatics, evolution, genomics, population genetics, selection, theory
Tagged gene flow, genomics, natural selection, population genetics
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