Category Archives: theory

Diving into the inbreeding depression

This post is going to be a little melodramatic, but I hope that despite all the reading on inbreeding depression, you won’t get depressed. As the media finally started feeding us all the catastrophic news about the impact of global … Continue reading

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Humans, selection, evolution and ecological timescales … a potent cocktail

It’s been awhile since I last was able to write for TME. But, finally, I’ve stolen away some time to write about a recent study in Ecology Letters that I couldn’t put down once I started reading it. Yes, it’s about mating … Continue reading

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Divergence and Linked Background Selection

We have widely discussed the reduction in neutral diversity due to demography and linked selection effects (e.g. selective sweeps and hitchhiking, or background selection) in several previous posts (e.g see here, here, and here). However, how linked selection affects neutral divergence … Continue reading

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The almighty CRISPR-Cas9 technology: The future of conservation?

In the first post on CRISPR-Cas9, I’ve explained how bacteria and archaea create a “database” of infections and use it as a form of prokaryotic immunization. This time, I’m going to concentrate on how biotechnology turns this natural phenomenon into … Continue reading

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The almighty CRISPR-Cas9 technology: How does it work?

CRISPR-Cas9 took the whole world of biology by storm. Selected Science’s 2015 Breakthrough of the Year, the CRISPR-Cas9 technology is revolutionizing science. Within five years of the official announcement (Jinek et al. 2012), it became the genome-editing technique of choice. … Continue reading

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Is equilibrium out of reach or are there some sneaky bouts of sex?

Reproductive systems impact the evolution of genetic diversity at the population level. Yet, we don’t know a lot about organisms that are partially clonal, despite the large component of biodiversity that dabbles in asexual reproduction to varying degrees. Clonal dynamics are … Continue reading

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Opening Pandora’s box: PSMC and population structure

Essentially, all models are wrong, but some are useful. — George Box Publication of the Li and Durbin’s 2011 paper titled “Inference of human population history from individual whole-genome sequences” was a milestone in the inference of demography. By allowing … Continue reading

Posted in bioinformatics, methods, Paleogenomics, population genetics, theory | Tagged , , , , | 5 Comments