Category Archives: population genetics

Identifying and quantifying fitness effects across loci

The following guest post by Ethan Jewett is cross-posted from the is cross-posted from the CEHG blog at Stanford. Enjoy! The degree to which similarities and differences among species are the result of natural selection, rather than genetic drift, is … Continue reading

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Posted in adaptation, genomics, population genetics, theory | Leave a comment

People behind the Science: Dr. Charles Goodnight

This month, we touch on the always-exciting topic of multilevel selection in our Q&A feature with Dr. Charles Goodnight of the University of Vermont. In addition to his work on multi-level selection, Dr. Goodnight has also studied the effects of founder … Continue reading

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Posted in interview, population genetics, quantitative genetics | Leave a comment

The broom of the system: Tracking soft selective sweeps in bacteria colonizing the gut

A growing body of population genetic evidence suggests that adaptive evolutionary change often proceeds via soft selective sweeps, in which beneficial mutations on multiple genetic backgrounds—and potentially at multiple loci—all increase in frequency, but none achieve fixation. This process has … Continue reading

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Posted in adaptation, microbiology, population genetics | Tagged , , | Leave a comment

What’s more isolating—environmental distance or … plain old distance?

We molecular ecologists spend a lot of time thinking about how we can differentiate the effects of natural selection acting on populations in different environments—local adaptation—from the simple isolating effects of, well, being in different places—isolation-by-distance. There’s a considerable literature … Continue reading

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The “sieve” of selection—and of scientific discovery

One of the many fundamental insights to come out of the early days of population genetics in the first decades of the 20th Century was J.B.S. Haldane’s discovery that, when it comes to natural selection, population size matters. As Haldane … Continue reading

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Posted in adaptation, population genetics | 1 Comment

On “triangulation” in genome scans

Guest contributor K.E. Lotterhos is a marine biologist at Wake Forest University, who studies evolutionary responses to fishing and climate change. You can find her on Twitter under then handle @dr_k_lo. A major goal of evolutionary biology is to understand the genetic … Continue reading

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Posted in adaptation, association genetics, genomics, methods, population genetics, quantitative genetics | 2 Comments

Caught in the act: how drug-resistance mutations sweep through populations of HIV

The following guest post by Meredith L. Carpenter is cross-posted from the CEHG blog at Stanford, and it describes recent work by Pleuni Pennings, who was featured in last week’s interview. Enjoy! It has been over 30 years since the … Continue reading

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Posted in adaptation, medicine, population genetics | 1 Comment

No reference genome? No problem! Demographic inference from genomic data in nonmodel insect populations

This guest article by Martin Sikora is cross-posted from the Computational, Evolutionary and Human Genomics blog at Stanford University. Reconstructing the demographic history of species and populations is one of the major goals of evolutionary genetics. Inferring the timing and … Continue reading

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Posted in genomics, next generation sequencing, population genetics | 2 Comments

How prevalent are non-overlapping generations?

Recently, the question of how prevalent in nature are truly non-overlapping generations has piqued my interest. There are many methodologies which make the assumption that generations are non-overlapping. Or in other cases, it is a simplification we may make to … Continue reading

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Posted in community, population genetics, quantitative genetics, Uncategorized | 6 Comments

Molecular ecology views: Metapopulation dynamics from lab flasks to tidal pools

Our co-blogger Peter Fields is joining the lab of Dieter Ebert at the University of Basel this fall, and he sent along these photos of the Ebert group’s long-term work on the metapopulation dynamics of parasite infection in Daphina water … Continue reading

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Posted in adaptation, Molecular Ecology views, population genetics | Tagged , , | Leave a comment