Category Archives: population genetics

Molecular Inversion Probes: phylogenomics without the excess?

The onset of the phylogenomic era has revolutionized molecular ecology and systematics, helping resolve relationships throughout the tree of life that have long eluded researchers working with only a handful of loci and morphological data. Phylogenetic studies of nonmodel organisms … Continue reading

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Posted in genomics, next generation sequencing, phylogenetics, phylogeography, population genetics, transcriptomics | Tagged , | Leave a comment

What do dolphins, bivalves and algae have in common?

Collaboration as it turns out, between three scientists interested in vertebrates, invertebrates and algae! A few days before we left for Evolution 2016 in Austin, one of my collaborators, Eric Pante, came to Charleston as the final stop in a North American … Continue reading

Posted in bioinformatics, blogging, career, conferences, DNA barcoding, haploid-diploid, natural history, phylogenetics, phylogeography, population genetics | Tagged , , , , , | Leave a comment

The Great Migration and African-American Genomic History

Over 45 million African-Americans share a recent common history largely shaped by “The Great Migration” (1910-1970) from out of the Southern United States. And yet, the admixture history of the African-American community, and its consequences for public health are little … Continue reading

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Catching evolution in the act with the Singleton Density Score

A recent study led by Jonathan K. Pritchard at Stanford University brought a media storm with catchy headlines in both of the flagship scientific outlets Nature and Science News. Aside from highlighting the question of preprints without peer review being … Continue reading

Posted in methods, mutation, population genetics, selection | Tagged , , , | 1 Comment

Ice-Age Euro-trips

Recent works that attempt to get at human migrations inside Europe paint a complex portrait of migratory events, admixture with archaic hominids, and adaptive evolution to new geographies, and a changing global climate. Analyzing whole genomes of 51 ancient humans … Continue reading

Posted in adaptation, evolution, genomics, natural history, Paleogenomics, population genetics, selection | Tagged , , , , , , , , | Leave a comment

Opening Pandora’s box: PSMC and population structure

Essentially, all models are wrong, but some are useful. — George Box Publication of the Li and Durbin’s 2011 paper titled “Inference of human population history from individual whole-genome sequences” was a milestone in the inference of demography. By allowing … Continue reading

Posted in bioinformatics, methods, Paleogenomics, population genetics, theory | Tagged , , , , | 3 Comments

RADseq and missing data: some considerations

Unlike Sanger sequencing, where loci are directly targeted for each individual and sequencing errors are relatively rare, massively multilocus datasets from next generation sequencing platforms are characterized by large amounts of missing data. This is particularly true for restriction digest … Continue reading

Posted in bioinformatics, genomics, methods, Molecular Ecology, the journal, next generation sequencing, phylogenetics, population genetics, theory | Tagged , , , | 5 Comments