Category Archives: genomics

Divergence and Linked Background Selection

We have widely discussed the reduction in neutral diversity due to demography and linked selection effects (e.g. selective sweeps and hitchhiking, or background selection) in several previous posts (e.g see here, here, and here). However, how linked selection affects neutral divergence … Continue reading

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Building bridges across the chaos

In a new review, Eldon and co-authors (in press) attempt to build a bridge across the chaos of genetic patchiness in the sea. They i) describe the patterns characterized as chaotic genetic patchiness, ii) discuss the potential causes of these patterns and … Continue reading

Posted in evolution, genomics, mutation, natural history, next generation sequencing, phylogenetics, phylogeography, population genetics, selection | Tagged , , , | Leave a comment

The almighty CRISPR-Cas9 technology: How does it work?

CRISPR-Cas9 took the whole world of biology by storm. Selected Science’s 2015 Breakthrough of the Year, the CRISPR-Cas9 technology is revolutionizing science. Within five years of the official announcement (Jinek et al. 2012), it became the genome-editing technique of choice. … Continue reading

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Is equilibrium out of reach or are there some sneaky bouts of sex?

Reproductive systems impact the evolution of genetic diversity at the population level. Yet, we don’t know a lot about organisms that are partially clonal, despite the large component of biodiversity that dabbles in asexual reproduction to varying degrees. Clonal dynamics are … Continue reading

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The trouble with PCR duplicates

The sequencing center just sent your lane of Illumina data. You’re excited. Life is great. You begin to process the data. You align the data. You check for PCR duplicates. 50 percent. Half of your data is garbage. Everything is … Continue reading

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Of microbes and men: Testing the neutral theory with the human microbiome

There is no doubt that one of the hottest current topics in microbiology revolves around the human microbiome. There have been a suite of recent studies we’ve highlighted, on organisms ranging from bees and mice, to humans. A quick google scholar search identifies … Continue reading

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Understanding the pieces of all those meeces: characterizing mice gut microbiota

In an age where a tremendous amount of data is generated, this week has seen some moves towards providing open access to extensive data sets. These attempts have been in the realm of chemistry as well as microbiology, where in a … Continue reading

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