Category Archives: genomics

And who made your beer?

In the spirit of it being almost Friday, and while we’re on the topic of your favorite beverages – perhaps wine puts you to sleep, couldn’t care less where it came from, but prefer the bitterness of lager beers at your … Continue reading

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Posted in adaptation, evolution, genomics, natural history, next generation sequencing, phylogenetics, population genetics, selection, speciation, yeast | Tagged , , , , | 1 Comment

The unforeseen genomic consequences of domestication

When a desired genome is selected for propagation, all mutations, beneficial, neutral, or deleterious, shift in frequency, and this sometimes can have unforeseen consequences. Natural selection takes the good with the bad. Beneficial and harmful mutations combine to provide a net … Continue reading

Posted in domestication, genomics, plants, selection, transcriptomics | Tagged , | Leave a comment

Where’s your wine from?

Human-mediated selection of yeast cultures has played a huge role in the development of numerous unique strains of Sacchromyces cerevisiae, often attributed to production of a wide variety of wines the world over. Previous studies have indicated a single domesticated … Continue reading

Posted in domestication, evolution, genomics, horizontal gene transfer, microbiology, Molecular Ecology, the journal, next generation sequencing, phylogenetics, phylogeography, population genetics, STRUCTURE, yeast | Tagged , , , | 1 Comment

Notes from Edmonton and #Botany2015

As noted previously, I broke with my usual habit and skipped the Evolution meetings this year. Instead, I attended Botany 2015, a joint meeting of multiple U.S. and Canadian plant-focused scholarly societies held in Edmonton, Alberta — I’d never been … Continue reading

Posted in bioinformatics, conferences, genomics, natural history, phylogenetics, plants, population genetics | Tagged | 1 Comment

Selection scans, and the genomics of adaptive/maladaptive introgression

Natural selection, and the adaptive evolution of hybrid reproductive incompatibilities post divergence are known to be major drivers of speciation. At the phenotype level, these manifest as fitness differences between introgressing populations. At the genomic level, speciation “genes” or “islands” … Continue reading

Posted in adaptation, Coevolution, evolution, genomics, Molecular Ecology, the journal, mutation, natural history, population genetics, selection, speciation, theory | Tagged , , , , | Leave a comment

PCA of multilocus genotypes in R

An earlier post from Mark Christie showed up on my feed on calculating allele frequencies from genotypic data in R, and I wanted to put together a quick tutorial on making PCA (Principal Components Analysis) plots using genotypes. I used … Continue reading

Posted in bioinformatics, genomics, howto, population genetics, R, software | Tagged , , | 4 Comments

Who came first – the Paleo- or Native American?

In yet another infamous Science vs Nature race, two studies published this Tuesday toss more cans of worms at the ongoing debate about the founding of the Americas – with disparate findings. Uh oh. Skoglund et al. Nature (2015) Genetic … Continue reading

Posted in genomics, next generation sequencing, Paleogenomics, population genetics | Tagged , , , , | 2 Comments

What do with all those pesky mtDNA reads in your NGS experiment

Have you ever noticed how many reads from your high throughput sequencing project map to the tiny fraction of your genome that is the mitochondrial genome (mtDNA)? Pretty much any NGS experiment (e.g., RNA-seq, DNA-seq, capture-based sequencing) leave you with … Continue reading

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IMa2p – Parallel Isolation with Migration Analyses

I figured that it was time to write an update on my post from a year ago on Bayesian MCMC in inferring ancestral demography. Recently, my postdoctoral advisor, Jody Hey and I released a version of the popular IMa2 program, … Continue reading

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The Butterfly Effect

This might just take the prize for the ‘spiciest’ story in molecular co-evolution for 2015, yet. While a lot of the press coverage sounds like caterpillar thanksgiving, the science behind this study stands for the almost incredible power of molecular phylogenetics … Continue reading

Posted in adaptation, evolution, genomics, natural history, population genetics, selection, speciation, transcriptomics | Tagged , , , , | 1 Comment