Category Archives: bioinformatics

Diving deep: Exploring microbial communities under the seafloor

As we all sat staring at three large monitors in the front of the room, the remotely operated vehicle (ROV) Jason hung on to a borehole observatory with one hydraulic arm as the other arm plugged our sampling equipment into … Continue reading

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Posted in bioinformatics, community ecology, fieldwork, genomics, metagenomics, microbiology, transcriptomics | Tagged , , , | Leave a comment

Star Trek Discovery made a debunked genome sequence into a plot point — but that’s not nearly the worst biology goof in the franchise

Anyone who’s been anywhere near my Twitter feed in the last month knows I’m pretty darned happy with Star Trek: Discovery, the latest iteration of the five-decade-old science fiction franchise. Discovery manages to build something new with the key elements … Continue reading

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Posted in bioinformatics, genomics, horizontal gene transfer | Tagged , | 2 Comments

We have the technology. Is sequencing getting better, smaller, faster?

Okay, I know some version of the phrase “recent developments in rapid and affordable sequencing have made blah blah blah possible…” is something you’ve probably read 10,000 times. However, third-generation sequencing platforms have turned out to be pretty darn astounding. … Continue reading

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Posted in bioinformatics, evolution, fieldwork, genomics, methods, next generation sequencing | Tagged , , , | Leave a comment

Non-model organisms are so hot right now

What makes a model organism? Well, as the name suggests, they are widely studied and have been adapted to a vast array of common genetic techniques. A few of the most often utilized organisms, which you are most likely already … Continue reading

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Posted in bioinformatics, domestication, evolution, genomics, next generation sequencing, yeast | Tagged , | Leave a comment

The largest mammalian genome is not polyploid

Some 40 million years ago in South America, following the arrival of the common ancestor of caviomorph rodents from the Old World, big changes were afoot. Specifically, the caviomorph colonists were beginning to give rise to an extant evolutionary progeny … Continue reading

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Posted in adaptation, bioinformatics, genomics, RNAseq, transcriptomics | Leave a comment

Easily aggregate bioinformatic sample output with one tool

Today I’m going to write about one of my favorite bioinformatic tools, MultiQC. If you’ve used it, you know why, and if you haven’t, prepare to be amazed. Many bioinformatic software produce output on a per-sample basis. That is, you … Continue reading

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Shared patterns of genomic diversity across populations of distantly related taxa

Genomic diversity is shaped by the complex interplay between the effects of genetic drift and natural selection among populations. Several of these effects, especially those of linked selection at neutral sites, adaptive introgression, and barriers to migration (often called “genomic … Continue reading

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Posted in adaptation, bioinformatics, birds, evolution, genomics, population genetics, selection | Tagged , , , , , | Leave a comment