Author Archives: Patrícia Pečnerová

About Patrícia Pečnerová

I am a PhD candidate at Stockholm University. I study paleogenomics of the last population of the woolly mammoth before its extinction and I am mainly interested in combining ancient DNA, population and conservation genomics to trace pre-extinction changes in genetic diversity.

Opening Pandora’s box: PSMC and population structure

Essentially, all models are wrong, but some are useful. — George Box Publication of the Li and Durbin’s 2011 paper titled “Inference of human population history from individual whole-genome sequences” was a milestone in the inference of demography. By allowing … Continue reading

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Posted in bioinformatics, methods, Paleogenomics, population genetics, theory | Tagged , , , , | 6 Comments

Disentangling the wolf-coyote admixture through an ancestry-based approach

Large carnivores like bears and wolves still pose a puzzle for systematics and population genetics. The more data we get, the more complex their evolutionary history seems to be.

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Posted in conservation, evolution, genomics, population genetics | Tagged , , , | Leave a comment

How to Clone a Mammoth: When science fiction becomes reality

When I explain that I study the woolly mammoth, sooner or later (and usually right away) comes the question, “Are you going to clone a mammoth?” From childish excitement to real scientific interest, the idea of cloning a mammoth raises … Continue reading

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Posted in book review, Paleogenomics | Tagged , , , | 1 Comment

Are genetic drift and inbreeding the same thing?

Does it ever happen to you that the more you try to understand something, the more difficult to understand it turns out to be? Recently, I’ve had such a problem with two of the very basic microevolutionary phenomena – genetic … Continue reading

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Posted in conservation, evolution, population genetics, quantitative genetics, theory, Uncategorized | Tagged , , , , , | Leave a comment

Petrous bone is the new black

I was just reading an article about skeletal reconstruction of another fascinating extinct species when my supervisor came to my office. I asked: “How about we sequence this creature’s genome?” He replied by asking where the animal had lived. As … Continue reading

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Posted in genomics, methods, Paleogenomics | Tagged , , , | 4 Comments

Single dispersal of modern humans to Eurasia

In a typical ancient DNA study where the number of authors exceeds the number of specimens (actually, equals this time), Cosimo Posth and colleagues sequenced 35 pre-Neolithic modern humans from Europe. By sequencing 35 mitochondrial DNA (mtDNA) genomes, Posth et … Continue reading

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Posted in evolution, genomics, natural history, Paleogenomics, population genetics | Tagged , , , | 5 Comments