Author Archives: Arun Sethuraman

About Arun Sethuraman

I am a computational biologist, and I build statistical models and tools for population genetics. I am particularly interested in studying the dynamics of structured populations, genetic admixture, and ancestral demography.

What does the island fox say?

Small populations are characterized by large drift and reduced efficacy of selection effects, which result in fixation of both advantageous and deleterious alleles, accumulation of homozygosity, and often reduction in population fitness. What with plummeting mammal populations across biota, understanding … Continue reading

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Sweeps and Demographic Inference

Population genetics presents us with numerous conundrums – several of which have to do with how the same genomic disposition can be “reached” over evolutionary time with multiple alternate demographic or selective processes. I have discussed several of these issues … Continue reading

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The why’s of sex

Sex isn’t quite what it seems – while superficially wasteful in an evolutionary sense (why inherit on only one half of your genes, when you can inherit all of them asexually, or why waste resources in mating when you don’t … Continue reading

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Posted in adaptation, evolution, genomics, mutation, natural history, next generation sequencing, population genetics, selection, theory, yeast | Tagged , , , , | Leave a comment

The Truth

Spoiler Alert: I’ve taken plenty of care to try and not spill the beans on any plotlines, but you have been forewarned that there may be some aspects of the science that’s discussed on the show that I attempt to … Continue reading

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Geographical Heat Maps in R

I go crazy for fancy data visualizations in R, and a figure in a recent publication has had me wondering if there is an easy way to incorporate density distributions (or as in their case, a distribution of f4 statistics, … Continue reading

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Posted in bioinformatics, howto, R, software | Tagged , | 2 Comments

The Neanderthal admixture plot thickens…

Previous studies of archaic admixture from Altai Neanderthals and Denisovans into modern humans outside of Africa have put forth several lines of evidence for gene flow from Neanderthals into common ancestors of Eurasian populations, from Denisovans into ancestors of modern … Continue reading

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Posted in bioinformatics, evolution, genomics, mutation, natural history, next generation sequencing, Paleogenomics, population genetics, speciation | Tagged , , , | 2 Comments

Genomics of Hybridization – Part II, Top three of 2015

Death Valley pupfishes (Cyprinodon) are among the most endangered vertebrates on earth, with small inbred populations, with heavy risks of extinction in extreme environments. Martin et al. (2016) in a recent publication quantify diversity and adaptability in a very small population … Continue reading

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Posted in bioinformatics, conservation, genomics, methods, natural history, next generation sequencing, population genetics, R, software, speciation, STRUCTURE, theory | Tagged , , , , | Leave a comment